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Beverly Wendland

Interim Dean

Wyman N623
410-516-4065
410-516-4100
bwendland@jhu.edu

Biography
Publications
  • In May 2014, Provost Robert Lieberman appointed Beverly Wendland, PhD, as interim dean of the Krieger School of Arts and Sciences. 

    A Johns Hopkins faculty member since 1998, Dr. Wendland has a strong knowledge of the Krieger School and its operations. She became chair of the Department of Biology in 2009, leading faculty, staff, and students during a period of renewal. She also holds a joint appointment in the Department of Biophysics.

    Dr. Wendland earned her bachelor’s degree in bioengineering at the University of California, San Diego, and her doctoral degree in neurosciences from Stanford University. She joined the Department of Biology at Johns Hopkins after completing her postdoctoral studies at the University of California, San Diego.

    A recipient of funding from the National Institutes of Health and the National Science Foundation, Dr. Wendland and her team study fundamental cellular processes using yeast cells as a simple model system. Discoveries about how yeast cell function can also teach us about human diseases, such as neurodegenerative diseases or cancer. Her lab’s work may ultimately identify new targets for treatments, such as enhanced delivery of gene therapies.

    Throughout her tenure at Johns Hopkins, Dr. Wendland has supported graduate and undergraduate students, serving as their mentor and a collaborator. An advocate for training future scientists to engage the power of interdisciplinary research, she was a member of the lab advisory committee during the construction of the new Undergraduate Teaching Laboratories, designed to foster collaboration across Homewood’s scientific community. Dr. Wendland was also a member of the Krieger School’s advisory committee on the status of women.

  • 2013

    Pierce, B.D., Toptygin, D. and Wendland, B. (2013). Pan1 is an intrinsically disordered protein with homotypic interactions. Proteins. (in press).

    Whitworth, K., Bradford, M.K., Camara, N. and B. Wendland. (2013). Targeted disruption of an EH-domain protein endocytic complex, Pan1-End3. Traffic. (in press).

    Goode, B.L. and Wendland, B. (2013). Actin and endocytosis in budding yeast. Genetics. (submitted).

    2012

    Umasaker, P.K., Sanker, S., Thieman, J.R., Chakraborty, S., Wendland, B., Tsang, M., Traub, L.M. (2012). Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nature Cell Biology. 14:488-501. 

    Prosser, D.C. and B. Wendland. (2012). Conserved roles for yeast Rho1 and mammalian RhoA GTPases in clathrin-independent endocytosis. Small GTPases. 3:229-235.

    2011

    Reider, A. and Wendland, B. (2011). Endocytic adaptors - social networking at the plasma membrane. Journal of Cell Science. 124:1613-22.

    Prosser, D.C., Drivas, T.G., Maldonado-Báez, L., and Wendland, B. (2011). Existence of a novel clathrin-independent endocytic pathway in yeast that depends on Rho1 and formin. Journal of Cell Biology. 195:657-71. 

    2010

    Prosser, D.C., Whitworth, K., and Wendland, B. (2010). Quantitative analysis of endocytosis with cytoplasmic pHluorin chimeras. Traffic. 11:1141-50.

    Prosser, D.C., Tran, D., Schooley, A., Wendland, B., and Ngsee, J.K (2010). A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Traffic.11:1347-62.

    Traub, L.M. and Wendland, B. (2010). Cell biology: How to don a coat. Nature. 465:556-557.

    Dores, M.R., Schnell, J.D., Maldonado-Baez, L., Wendland, B., and Hicke, L. (2010). The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Traffic. 11:151-160. 

    2009

    Boettner, D.R., D’Agostino, J.L., Torres, O.T., Daugherty-Clarke, K., Uygur, A., Reider, A., Wendland, B., Lemmon, S.K., and Goode, B.L. (2009). The F-BAR domain protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocysptic patch formation.Current Biology. 19:1979-1987.

    Burston, H.E., Maldonado-Báez, L., Davey, M., Montpetit, B., Schluter, C., Wendland, B., and Conibear, E. (2009). Regulators of Yeast Endocytosis Identified by Systematic Quantitative Analysis. J. Cell Biol. 185:1097-1110.

    Pierce, B.D. and Wendland, B. (2009). Sequence of the yeast protein expression plasmid pEG(KT).Yeast. 26:349-353.

    McPherson, P.S., Ritter, B., and Wendland, B. (2009). Clathrin-mediated endocytosis. Trafficking Inside Cells: Pathways, Mechanisms and Regulation. Molecular Biology Intelligence Unit, Landes Bioscience, Springer Science + Business Media, LLC. Editors: N. Segev, A. Alfonso, G. Payne and J. Donaldson. Chapter 9, pages 159-182.

    Mukherjee, D., Coon, B.G., Edwards III, D.F., Hanna, C.B., Longhi, S.A., McCaffery, J.M., Wendland, B., Retegui, L.A., Bi, E., and Aguilar, R.C. (2009). The yeast endocytic protein Epsin-2 functions in a cell division signaling pathway. J. Cell Sci. 122:2543-2464.

    Reider, A., Barker, S.L., Im, Y. J., Mishra, S., Hurley, J.M., Traub, L. and Wendland, B. Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J. 28:3103-3116.

    2008

    Maldonado-Báez, L., Dores, M.R., Perkins, E.M., Drivas, T.G., Hicke, L., and Wendland, B. (2008). Interaction between Epsin/Yap180 Adaptors and the Scaffolds Ede1/Pan1 Is Required for Endocytosis. Mol Biol Cell. 19:2936-2948.

    2007

    Barker, S.L., Lee, L., Pierce, B.D., Maldonado-Báez, L., Drubin, D., and Wendland, B. (2007). Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis. Mol. Biol. Cell. 18:2893-2903.

    2006

    Maldonado-Báez, L. and Wendland, B. (2006). Endocytic Adaptors: Recruiters, coordinators and regulators. Trends in Cell Biology. 16: 505-513.

    Aguilar, R.C., Longhi, S.A., Shaw, J.D., Yeh, L.-Y., Kim, S., Schon, A., Freire, E., Hsu, A., Watson, H.A., McCormick, W.K., and Wendland, B. (2006). Epsin ENTH domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase activating proteins. Proc Natl Acad Sci U S A. 103:4116-4121. [Cover highlight, and accompanying Commentary] 

    2005

    Saiardi, A., Resnick, A.C., Snowman, A.M., Wendland, B., and Snyder, S.H. (2005). Inositol pyrophosphates mediate cell death by regulating PI3-related protein kinases. Proc Natl Acad Sci USA. 102:1911-1914.

    Aguilar R.C. and Wendland B. (2005). Endocytosis of membrane receptors: Two pathways are better than one. Proc Natl Acad Sci U S A. 102:2679-2680.

    Katzmann, D.J. and Wendland, B. (2005). Analysis of ubiquitin-dependent protein sorting within the endocytic pathway in Saccharomyces cerevisiaeMethods in Enzymology. 399:192-211. 

    2004

    Watson, H.A., Von Zastrow, M., and Wendland, B. Endocytosis. (2004). In Encyclopedia of Molecular Cell Biology and Molecular Medicine. Second edition. Edited by Robert A. Myers. Wiley-VCH. Volume 4, 181-224.

    Miliaras, N.B. and Wendland, B. (2004). EH-proteins: multivalent regulators of endocytosis (and other pathways). Cell Biochemistry and Biophysics. 41:295-318.

    Miliaras, N.B., Park, J.-H., and Wendland, B. (2004). The function of the endocytic scaffold protein Pan1p depends on multiple domains. Traffic. 5:963-978.

    2003

    Aguilar, R.C., Watson, H.A., and Wendland, B. (2003). The yeast epsin Ent1 is recruited to membranes through multiple independent interactions. JBC 278(12):10737-43.

    Aguilar, R.C. and Wendland, B. (2003). Ubiquitin: not just for proteasomes anymore. Curr. Opin. in Cell Biol. 15: 184-90.

    Shaw, J.D., Hama, H., Sohrabi, F., DeWald, D.B., and Wendland, B. (2003). Phosphatidylinositol (3,5) bisphosphate is required for delivery of endocytic cargo into the multivesicular body.Traffic 4:479-90.

    Overstreet, E., Chen, X., Wendland, B., and Fischer, J.A. (2003). Either portion of a severed Drosophila epsin (Liquid Facets) functions in the internalization of Delta in the developing eye.Curr Biol. 13:854-60.

    Sekiya-Kawasaki, M., Cope, M.J.T.V., Groen, A.C., Kaksonen, M., Zhang, C., Shokat, K.M., Wendland, B., McDonald, K.L., McCaffery, J.M., and Drubin, D.G. (2003). Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J. Cell Biology. 162:765-72.

    Meriin, A.B., Zhang, X., Miliaras, N.B., Kazantsev, A., Chernoff, Y.O., McCaffery, J.M., Wendland, B., and Sherman, M.Y. (2003). Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol. Cell. Biol. 23:7554-65.

    Baggett, J.J., D’Aquino, K.E., and Wendland, B. (2003). The Sla2p Talin domain plays a role in endocytosis in Saccharomyces cerevisiaeGenetics. 165:1661-1674.

    Baggett, J.J., Shaw, J.D., and Wendland, B. (2003). Fluorescent Labeling of Yeast. Edited by J. Lippincott-Schwartz and P. Matsudaira. Current Protocols in Cell Biology, Unit 4.13. 

    2002

    Babst, M., Katzmann, D.J., Snyder, W.B., Wendland, B., and Emr, S.D. (2002). Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Bodies. Dev. Cell. 3:283-9.

    Vida, T.A. and Wendland, B. (2002). Flow cytometry for selection of yeast membrane trafficking mutants. Edited by C. Guthrie and G. Fink. Methods in Enzymology 351: 623-631.

    Hurley, J.H. and Wendland, B. (2002). Endocytosis: Driving membranes around the bend. Cell. 111:143-6.

    Saiardi, A., Sciambi, C.J., McCaffery, J.M., Wendland, B., and Snyder, S.H. (2002). Inositol pyrophosphates regulate endocytic trafficking. Proc. Natl. Acad. Sci. 99:14206-11.

    Wendland, B. Epsins: adaptors in endocytosis? (2002) Nature Rev. Mol. Cell Biol. 3:971-7.

    2001

    Baggett, J.J., and Wendland, B. (2001). Clathrin function in yeast endocytosis. Traffic.2(5):297- 302.

    Wang, G., McCaffery, J.M., Wendland, B., Dupre, S., Haguenauer-Tsapis, R., and Huibregtse, J.M. (2001). Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway. Mol Cell Biol. 21:3564-75.

    Wendland, B. (2001). Round-trip ticket:  Re-cycling to the plasma membrane requires RME-1. News and Views in Nature Cell Biol. 3(6):E133-5.

    Wendland, B. (2001). Everything you ever wanted to know about endocytosis. Review of:Endocytosis, edited by M. Marsh. Volume 36 in Frontiers in Molecular Biology series, edited by B.D. Hames and D.M. Glover. Oxford University Press, 2001. Nature Cell Biology. 3: E254.

    Duncan, M.C., Cope, M.J.T.V., Goode, B.L., Wendland, B., and Drubin, D.G. (2001). Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex. Nature Cell Biology. 3(7):687-90.

    Shaw, J.D., Cummings, K.B., Huyer, G., Michaelis, S., and Wendland, B. (2001). Yeast as a model system for studying endocytosis. Experimental Cell Research. 271: 1-9.

    Watson, H.A., Cope, M.J.T.V., Groen, A.C., Drubin, D.G. and Wendland, B. (2001). In vivo role for Actin Regulating Kinases in endocytosis and yeast epsin phosphorylation. Mol. Biol. Cell. 12(11):3668-79. 

    Postdoctoral Work

    Wendland, B., Steece, K.E., and Emr, S.D. (1999) Yeast Epsins contain an essential N-terminal ENTH domain, bind clathrin, and are required for endocytosis. EMBO Journal. 18(16):4383-4393.

    Kay, B.K., Yamabhai, M., Wendland, B., and Emr, S.D. (1998). Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Science8: 435-438.

    Wendland, B. and Emr, S.D. (1998). Pan1p, yeast eps15, functions as a multivalent adaptor that mediates protein-protein interactions essential for endocytosis. J. Cell Biol. 141: 71-84.

    Wendland, B. (1998). For budding yeast investigators. Review of: Methods in Yeast Genetics by A. Adams, D.E. Gottschling, C.A. Kaiser, and T. Stearns. Cold Spring Harbor Laboratory Press, 1997. Trends Cell Biol. 8:462-463.

    Babst, M., Wendland, B., Estepa, E.J., and Emr, S.D. (1998). The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17: 2982-2993.

    Wendland, B., Emr, S.D., and Riezman, H. (1998). Protein traffic in the yeast endocytic and vacuolar sorting pathways. Curr. Opin. in Cell Biol. 10: 513-522.

    Wendland, B., McCaffery, J.M., Xiao, Q. and Emr, S.D. (1996). A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J. Cell Biol. 135: 1485-1500. 

    Graduate Work

    Malgaroli, A., Ting, A.E., Wendland, B., Bergamaschi, A., Villa, A., Tsien, R.W., and Scheller, R.H. (1995). Presynaptic component of long-term potentiation visualized at individual hippocampal synapses. Science 268, 1624-1628.

    Wendland, B., Schweizer, F.E., Ryan, T.A., Nakane, M., Murad, F., Scheller, R.H., and Tsien, R.W. (1994). Existence of nitric oxide synathase in rat hippocampal pyramidal cells. Proc. Natl. Acad. Sci.  91, 2151-2155.

    Wendland, B. and Scheller, R.H. (1994). Molecular mechanism of synaptic vesicle docking and membrane fusion. Semin Neurosci 6: 167-76.

    Wendland, B. and Scheller, R.H. (1994). Secretion in AtT-20 cells stably transfected with soluble synaptotagmins. Mol. Endocrinology 8, 1070-1082.

    Miller, K.G., Wendland, B., and Scheller, R.H. (1993). Identification of a 34 kd synaptic vesicle and nervous system specific protein. Brain Res., 616, 99-104.

    Ryan, T.A., Reuter, H., Wendland, B., Schweizer, F.E., Tsien, R.W., and Smith, S.J. (1993). The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron 11: 713-724.

    Wendland, B., Miller, K.G., Schilling, J. and Scheller, R.H. (1991). Differential expression of the p65 gene family. Neuron. 6, 993-1007.

    Ngsee, J.K., Miller, K., Wendland, B., and Scheller, R.H. (1990). Multiple GTP-binding proteins from cholinergic synaptic vesicles. J. Neuroscience. 10, 317-322.

    Ngsee J.K., Trimble W.S., Elferink L.A., Wendland B., Miller K., Calakos N., Scheller R.H. (1990). Molecular analysis of proteins associated with the synaptic vesicle membrane. Cold Spring Harb Symp Quant Biol. 55:111-8.