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The Zanvyl Krieger Mind/Brain Institute

Somatosensory Lab

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Dr. Manuel Gomez-Ramirez

Assistant Research Scientist,
Phone: (410) 516-6412

Research Interests:

  • Neural mechanisms of object perception in touch
  • Mechanisms of selective attention and multisensory integration

The broad aim of my current research is to understand the neural mechanisms mediating 2D tactile stimulus processing in the somatosensory modality. My research efforts are devoted towards studying form (e.g. orientation and curvature) and motion perception in the tactile system. Furthermore, I investigate how selective attention modulates the activity within and across neural populations encoding the relevant features of a stimulus. More recentely, I am studying the neural mechanisms underlying integration of cutaneous sensory features and proprioceptive signals from the hand.

I employ neurophysiological techniques in awake-behaving animals and complement these studies with human psychophysical data and computational modeling.


Peer-Reviewed Publications:

  • Gomez-Ramirez M, Trzcinski NK, Mihalas S,  Niebur E, Hsiao SS (In press). Temporal correlation mechanisms and their role in feature selection: A single-unit study in primate somatosensory cortex. PLoS Biology.
  • Abeles IY, Gomez-Ramirez M (2014). Impairments in background and event-related alpha-band oscillatory activity in patients with schizophrenia. PLoS One. 9(3):e91720. PMID: 24646909
  • Pei YC, Chang TY, Lee TC, Saha S, Lai HY, Gomez-Ramirez M, Chou SW, Wong AM (2013). Cross-modal sensory integration of visual-tactile motion information: instrument design and human psychophysics. Sensors (Basel), 13(6):7212-23. PMID:23727955
  • Gomez-Ramirez M, Kelly SP, Molholm S, Sehatpour P, Schwartz T, & Foxe JJ (2011). Oscillatory Sensory Selection Mechanisms Mediate Intersensory Attention to Auditory and Visual Inputs: A Human Intracranial Electrophysiological Study. Journal of Neuroscience, 31(50):18556-67. PMID: 22171054
  • Gomez-Ramirez M, Kelly SP, Molholm S, Sehatpour P, Schwartz T, & Foxe JJ (2011). Oscillatory Sensory Selection Mechanisms Mediate Intersensory Attention to Auditory and Visual Inputs: A Human Intracranial Electrophysiological Study. Journal of Neuroscience, 31(50):18556-67. PMID: 22171054
  • Leitman DI, Sehatpour P, Garidis C, Gomez-Ramirez M, Javitt DC (2011). Preliminary Evidence of Pre-Attentive Distinctions of Frequency-Modulated Tones that Convey Affect. Front Hum Neurosci. 5:96. PMID: 22053152
  • Leavitt VM, Molholm S, Gomez-Ramirez M & Foxe JJ (2011). “What” and “Where” in auditory sensory processing: A high-density electrical mapping study of distinct neural processes underlying sound object recognition and sound localization. Frontiers in Integrative Neuroscience, 5:23. PMID: 21734870
  • Ross LA, Molholm S, Blanco D, Gomez-Ramirez M, Saint-Amour D, Foxe JJ (2011). The development of multisensory speech perception continues into the late childhood years. Eur J Neurosci, 33(12):2329-2337. PMID: 21615556
  • Lucan JN, Foxe JJ, Gomez-Ramirez M, Sathian K, Molholm S (2009). Somatosensory object recognition recruits human lateral occipital complex during early perceptual processing. Human Brain Mapping, 31(11):1813-21. PMID: 20162607
  • Katz R, De Sanctis P, Mahoney JR, Sehatpour P, Murphy C, Gomez-Ramirez M, Alexopoulos G, Foxe JJ. Cognitive Control in Late-Life Depression: Response inhibition deficits and dysfunction of the Anterior Cingulate Cortex. American Journal of Geriatric Psychiatry, 18(11):1017-25. PMID: 20808083
  • Kelly SP, Gomez-Ramirez M, Foxe JJ (2009). The strength of anticipatory spatial biasing predicts target discrimination at attended locations: A human EEG study. European Journal of Neuroscience, 30(11):2224-34. PMID: 19930401
  • De Sanctis P, Gomez-Ramirez M, Sehatpour P, Wylie GR, Foxe JJ (2009). Preserved executive function in high-performing elderly is driven by large-scale recruitment of prefrontal cortical mechanisms. Human Brain Mapping, 30(12):4198-214. PMID: 19572310
  • Gomez-Ramirez M, Kelly SP, Montesi JL, & Foxe JJ (2009). The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topography, 22(1):44-51. PMID: 18841456
  • Kelly SP, Gomez-Ramirez M, Montesi JL, & Foxe JJ (2008). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. Journal of Nutrition, 138(8):1572S-1577S. PMID: 18641209
  • Kelly SP, Gomez-Ramirez M, Foxe JJ (2008). Spatial Attention Modulates Initial Afferent Activity in Human Primary Visual Cortex. Cerebral Cortex, 18(11):2629-36. PMID: 18321874
  • Gomez-Ramirez M., Higgins BA., Rycroft JA., Owen GN., Mahoney J., Shpaner M., and Foxe JJ (2007). The deployment of Intersensory Selective Attention: A high-density electrical mapping study of the effects of theanine. Journal of Clinical Neuropharmacology, 30 (1): 25 – 38. PMID: 17272967
  • Senkowski D., Gomez-Ramirez M., Lakatos P., Wylie GR, Molholm S., Schroeder CE., and Foxe JJ (2007). Multisensory processing and induced oscillations: A new analysis method for human and non-human primate data. Experimental Brain Research, 177(2): 184-195. PMID: 17051387
  • Molholm S., Sehatpour P., Mehta AD., Shpaner M., Gomez-Ramirez M., Dyke JP, Labar DR., Schwartz TH., and Foxe JJ (2006). Human intracranial recordings of audiovisual multisensory integration in superior parietal lobule. Journal of Neurophysiology, 96(2): 721-729. PMID: 16687619
  • Senkowski D, Molholm S, Gomez-Ramirez M, and Foxe JJ (2005). Oscillatory Beta Activity Predicts Response Speed during a Multisensory Audiovisual Reaction Time Task: A High-Density Electrical Mapping Study. Cerebral Cortex, 16(11): 1556-1565. PMID: 16357336
  • Santucci AC, Capodilupo S, Bernstein J, Gomez-Ramirez M, Milefsky R, and Mitchell H. (2004). Cocaine in adolescent rats produces residual memory impairments that are reversible with time. Neurotoxicology and Teratology, 26(5): 651-661. PMID: 15315814
  • Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD. (2003) Altered A{beta} Formation and long-term potentiation in a Calsenilin knock-out. Journal of Neuroscience 27: 9097-9106. PMID: 14534243

Book Chapters:

  • Hsiao S, Gomez-Ramirez M (In press). Neural Coding of Tactile Perception. In The Cognitive Neurosciences. Cambridge, MA: The MIT Press.
  • Hsiao S, Gomez-Ramirez M (2013). Neural Mechanisms of Tactile Perception. In Handbook of Psychology (pp. 206-239). Hoboken, NJ: John Wiley & Sons.
  • Hsiao S, Gomez-Ramirez M (2011). Touch. In Neurobiology of Sensation and Reward (pp. 141-159). Boca Raton, FL: CRC Press.

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