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Research Papers

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Goel, A., L. W. Xu, K. P. Snyder, L. Song, Y. Goenaga-Vazquez, A. Megill, K. Takamiya, R. L. Huganir, and H.-K. Lee (2011) Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. PLoS One 6 (3): e18264. Web Access

Wang H., L. Song, A. Lee, F. Laird, P. C. Wong, and H.-K. Lee (2010) Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors . Journal of Neuroscience 30(41): 13808-13813. View PDF File

Gao, M., K. Sossa, L. Song, L. Errington, L. W. Cummings, H. Hwang, D. Kuhl, P. Worley, and H.-K. Lee (2010) A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex. Journal of Neuroscience 30: 7168-7178. View PDF File

Jiang, B.*, S. Huang*, R. de Pasquale, D. Millman, L. Song, H.-K. Lee , T. Tsumoto, and A. Kirkwood (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66: 248-259. View PDF File

Lee, H.-K ., K. Takamiya, K. He, L. Song, and R. L. Huganir (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology 103: 476-489. View PDF File

He, K., L. Song, L. W. Cummings, J. Goldman, R. L. Huganir, and H.-K. Lee (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proceedings of National Academy of Sciences USA 106(47): 20033-20038.
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Chung, H. J. and H.-K. Lee (2009) Constructing a road map from synapses to behavior. EMBO Reports 10 (9): 958-962. View PDF File

Kreczko, A., A. Goel , L. Song, and H.-K. Lee (2009) Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex . Neural Plasticity 2009: 415135. Web Access

Wang, H., L. Song, F. M. Laird, P. C. Wong, and H.-K. Lee (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. Journal of Neuroscience 28: 8677-8681. View PDF File.

Crombag, H. S., J. M. Sutton, K. Takamiya, H.-K. Lee, P. C. Holland, M. Gallagher, and R. L. Huganir (2008) A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behavioural Brain Research 191: 178-183. View PDF File

Lee, H.-K. and R. L. Huganir (2008) AMPA receptor regulation and the reversal of synaptic plasticity - LTP, LTD, depotentiation, and dedepression. In: Comprehensive Handbook of Learning and Memory (Chief Editor: J. Byrne, Volume Editor: J. D. Sweatt), Elsevier press.

Seol, G. H., J. Ziburkus, S. Huang, L. Song, I. T. Kim, K. Takamiya, R. L. Huganir, H.-K. Lee, and A. Kirkwood (2007) Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity. Neuron 55: 919-929. View PDF File

Lee, H.-K., K. Takamiya, K. Kameyama, K. He, S. Yu , L. Rossetti, D. Wilen, and R. L. Huganir (2007) Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Molecular and Cellular Neuroscience. View PDF File

Goel, A. and H.-K. Lee (2007) Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex. Journal of Neuroscience 27 (25): 6692-6700. View PDF File

Laird, F. M., M. H. Farah, H.-K. Lee, A. V. Savonenko, D. L. Price, and P. C. Wong (2007) Beta-secretase: Physiological Role and Target Validation. In: Alzheimer's Disease (Editors: S. S. Sisodia and R. E. Tanzi). Springer.

Goel, A., B. Jiang , L.W. Xu , L. Song ,A. Kirkwood , and H.-K. Lee(2006) Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience. Nature Neuroscience 9 (8): 1001-1003. View PDF File and supplementary materials

Lee, H.-K. (2006) Synaptic plasticity and phosphorylation. Pharmacology & Therapeutics 112: 810-832. View PDF File

Lee, H.-K. (2006) AMPA receptor phosphorylation in synaptic plasticity: Insights from knockin mice. In: The Dynamic Synapse: Molecular methods in ionotropic receptor biology (Editors: J. Kittler and S. J. Moss). CRC press.

Laird, F. M., H. Cai, A. V. Savonenko,M. H. Farah, K. He, T. Melnikova, H. Wen, H.-C. Chiang, G. Xu, V. E. Koliatsos, D. R. Borchelt, D. L. Price, H.-K. Lee, and P. C. Wong(2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid- amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. Journal of Neuroscience25(50):11693-11709. View PDF File

Lee, H.-K., S. S. Min, M. Gallagher, and A. Kirkwood(2005) NMDA receptor-independent long-term depression correlates with successful aging in rats. Nature Neuroscience 8: 1657-1659. View PDF File

Hayashi, M. L., S.-Y. Choi, B. S. S. Rao, H.-Y. Jung, H.-K. Lee, D. Zhang, S. Chattarji, A. Kirkwood, and S. Tonegawa (2004) Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42: 757-771. View PDF File

Lee, H.-K., K. Takamiya, J.-S. Han, H. Man, C.-H. Kim, G. Rumbaugh, S. Yu, C. He, L. Ding, R. S. Petralia, R. J. Wenthold, M. Gallagher, and R. L. Huganir (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112: 631-643. View PDF File

Kim, J. H., H.-K. Lee, K. Takamiya, R. L. Huganir (2003) The role of Synaptic GTPase-Activating Protein in neuronal development and synaptic plasticity. Journal of Neuroscience 23: 1119-1124. View PDF File

Chao, S. Z., W. Lu, H.-K. Lee, R. L. Huganir, and M. E. Wolf (2002) D1 dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures. Journal of Neurochemistry 81: 984-992. View PDF File

Choi, S.-Y., B. Morales, H.-K. Lee, and A. Kirkwood (2002) Long-term depression is reduced in the visual cortex of GAD65 knockout mice. Journal of Neuroscience 22: 5271-5276. View PDF File

Kim, C.-H., H. J. Chung,, H.-K. Lee, J. Xia and R. L. Huganir (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proceedings in National Academy of Sciences USA 98: 11725-11730. View PDF File

Lee, H.-K. , M. Barbarosie, K. Kameyama, M. F. Bear and R. L. Huganir (2000) Regulation of distinct AMPA receptor phosphorylation sites during bi-directional synaptic plasticity. Nature 405: 955-959. View PDF File

Banke, T. G., D. Bowie, H.-K. Lee, R. L. Huganir, A. Schousboe, and S. F. Traynelis (2000) Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase and calcineurin. Journal of Neuroscience 20: 89-102. View PDF File

Lee, H.-K. and R. L. Huganir (1999) Phosphorylation of glutamate receptors. In: Handbook of Experimental Pharmacology: Ionotropic Glutamate Receptors in the CNS (Editors: P. Jonas and H. Monyer). Springer-Verlag, Heidelberg.

Lee, H.-K., K. Kameyama, R. L. Huganir and M. F. Bear (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21: 1151-1162. View PDF File

Kameyama, K., H.-K. Lee, M. F. Bear and R. L. Huganir (1998) Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron 21: 1163-1175. View PDF File

Kirkwood, A., H.-K. Lee and M. F. Bear (1995) Co-regulation of long-term potentiation and experience-dependent plasticity in visual cortex by age and experience. Nature 375:328-331. View PDF File

Selig, D. K., H.-K. Lee, M. F. Bear and R. C. Malenka (1995) Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation. Journal of Neurophysiology 74 (3): 1075-1082. View PDF File

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