Award: Woodrow Wilson
HIF-1 is Epigenetically Regulated by Redox Peroxiredoxin 2 and 4 in Cancer
HIF-1 is the master, transcriptional regulator under hypoxia, activating thousands of genes involved in cancer biology, tumorigenesis, metastatisis, and metabolism. The peroxiredoxins (PRDX) are a family of proteins that use a thioredoxin system to alleviate oxidative stress. We found that in cancer, PRDX is able to suppress HIF-1 through a epigenetic mechanism that involves JMJD3. Further, we found that higher PRDX is correlated with higher overall survival, likely through inhibition of HIF-1. Lastly, a RNAseq delineating the transcriptome of these cancer cells identified novel HIF-1 target genes suppressed by PRDX2 and 4.
Mentor: Dr. Gregg L. Semenza, Johns Hopkins School of Medicine