Control of stem cell self-renewal and differentiation by targeting SAICAR biosynthesis
The application of stem cells in treating diseases has been restricted by the difficulty of controlling their self-renewal and differentiation. By targeting a metabolic process specific to undifferentiated cells, we will develop a method that controls stem cell self-renewal and differentiation. In this project, I will test whether the biosynthesis of 1-(5’-phosphoribosyl)-5-aminoimidazole-4-succinocarboxamide (SAICAR) can be targeted for the purpose. I will test the hypothesis using human induced pluripotent cells and shRNA and cell-permeable compounds targeting the biosynthesis of SAICAR.
Mentor: Dr. Young-Sam Lee