James B. Knapp Dean
Beverly Wendland PhD has been the James B. Knapp Dean of the Krieger School of Arts and Sciences since 2015.
A Johns Hopkins faculty member since 1998 in the Department of Biology, Dr. Wendland’s research examines fundamental cellular processes using yeast cells as a simple model system. Her lab’s work could potentially identify new targets for treatments such as enhanced delivery of gene therapies. In 2015, she was named a fellow of the American Association for the Advancement of Science for her groundbreaking studies on the genetic, molecular, biochemical, and biophysical mechanisms underlying endocytosis. Dr. Wendland has been a recipient of funding from the National Institutes of Health and the National Science Foundation. She is also the recipient of the Burroughs Wellcome Fund New Investigator Award in the Pharmacological Sciences and the March of Dimes Basil O’Connor Award.
Dr. Wendland oversees the Krieger School of Arts and Sciences, which has 22 highly ranked academic departments within the natural sciences, social sciences, and the humanities.
During her tenure as dean, Dr. Wendland guided the school through a multi-million dollar campaign, raising $747 million. She has also been key in implementing the SNF Agora Institute, a hub for research, teaching, and practice to strengthen global democracy by improving and expanding civic engagement and productive dialogue.
A noted educator and expert in higher education, Dr. Wendland has been appointed co-chair of the university’s Second Commission on Undergraduate Education, an effort to develop a new model for undergraduate education. She is an advocate for training future scientists to engage the power of interdisciplinary research. Dr. Wendland completed the Johns Hopkins Leadership Program for Women Faculty as a member of the fifth cohort.
Dr. Wendland earned her bachelor’s degree in bioengineering at the University of California, San Diego, and her doctoral degree in neurosciences from Stanford University. She joined the Department of Biology at Johns Hopkins after completing her postdoctoral studies at the University of California, San Diego.
Goode, B.L., Eskin, J.A. and Wendland, B. (2015). Actin and endocytosis in budding yeast. Genetics. 199(2):315-58.
Pierce, B.D., Toptygin, D. and Wendland, B. (2013). Pan1 is an intrinsically disordered protein with homotypic interactions. Proteins. 81(11):1944-63.
Whitworth, K., Bradford, M.K., Camara, N. and B. Wendland. (2013). Targeted disruption of an EH-domain protein endocytic complex, Pan1-End3. Traffic. 15(1):43-59.
Umasaker, P.K., Sanker, S., Thieman, J.R., Chakraborty, S., Wendland, B., Tsang, M., Traub, L.M. (2012). Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nature Cell Biology. 14:488-501.
Prosser, D.C. and B. Wendland. (2012). Conserved roles for yeast Rho1 and mammalian RhoA GTPases in clathrin-independent endocytosis. Small GTPases. 3:229-235.
Reider, A. and Wendland, B. (2011). Endocytic adaptors - social networking at the plasma membrane. Journal of Cell Science. 124:1613-22.
Prosser, D.C., Drivas, T.G., Maldonado-Báez, L., and Wendland, B. (2011). Existence of a novel clathrin-independent endocytic pathway in yeast that depends on Rho1 and formin. Journal of Cell Biology. 195:657-71.
Prosser, D.C., Whitworth, K., and Wendland, B. (2010). Quantitative analysis of endocytosis with cytoplasmic pHluorin chimeras. Traffic. 11:1141-50.
Prosser, D.C., Tran, D., Schooley, A., Wendland, B., and Ngsee, J.K (2010). A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Traffic. 11:1347-62.
Traub, L.M. and Wendland, B. (2010). Cell biology: How to don a coat. Nature. 465:556-557.
Dores, M.R., Schnell, J.D., Maldonado-Baez, L., Wendland, B., and Hicke, L. (2010). The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Traffic. 11:151-160.
Boettner, D.R., D’Agostino, J.L., Torres, O.T., Daugherty-Clarke, K., Uygur, A., Reider, A., Wendland, B., Lemmon, S.K., and Goode, B.L. (2009). The F-BAR domain protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocysptic patch formation.Current Biology. 19:1979-1987.
Burston, H.E., Maldonado-Báez, L., Davey, M., Montpetit, B., Schluter, C., Wendland, B., and Conibear, E. (2009). Regulators of Yeast Endocytosis Identified by Systematic Quantitative Analysis. J. Cell Biol. 185:1097-1110.
Pierce, B.D. and Wendland, B. (2009). Sequence of the yeast protein expression plasmid pEG(KT).Yeast. 26:349-353.
McPherson, P.S., Ritter, B., and Wendland, B. (2009). Clathrin-mediated endocytosis. Trafficking Inside Cells: Pathways, Mechanisms and Regulation. Molecular Biology Intelligence Unit, Landes Bioscience, Springer Science + Business Media, LLC. Editors: N. Segev, A. Alfonso, G. Payne and J. Donaldson. Chapter 9, pages 159-182.
Mukherjee, D., Coon, B.G., Edwards III, D.F., Hanna, C.B., Longhi, S.A., McCaffery, J.M., Wendland, B., Retegui, L.A., Bi, E., and Aguilar, R.C. (2009). The yeast endocytic protein Epsin-2 functions in a cell division signaling pathway. J. Cell Sci. 122:2543-2464.
Reider, A., Barker, S.L., Im, Y. J., Mishra, S., Hurley, J.M., Traub, L. and Wendland, B. Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J. 28:3103-3116.
Maldonado-Báez, L., Dores, M.R., Perkins, E.M., Drivas, T.G., Hicke, L., and Wendland, B. (2008). Interaction between Epsin/Yap180 Adaptors and the Scaffolds Ede1/Pan1 Is Required for Endocytosis. Mol Biol Cell. 19:2936-2948.
Barker, S.L., Lee, L., Pierce, B.D., Maldonado-Báez, L., Drubin, D., and Wendland, B. (2007). Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis. Mol. Biol. Cell. 18:2893-2903.
Maldonado-Báez, L. and Wendland, B. (2006). Endocytic Adaptors: Recruiters, coordinators and regulators. Trends in Cell Biology. 16: 505-513.
Aguilar, R.C., Longhi, S.A., Shaw, J.D., Yeh, L.-Y., Kim, S., Schon, A., Freire, E., Hsu, A., Watson, H.A., McCormick, W.K., and Wendland, B. (2006). Epsin ENTH domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase activating proteins. Proc Natl Acad Sci U S A. 103:4116-4121. [Cover highlight, and accompanying Commentary]
Saiardi, A., Resnick, A.C., Snowman, A.M., Wendland, B., and Snyder, S.H. (2005). Inositol pyrophosphates mediate cell death by regulating PI3-related protein kinases. Proc Natl Acad Sci USA. 102:1911-1914.
Aguilar R.C. and Wendland B. (2005). Endocytosis of membrane receptors: Two pathways are better than one. Proc Natl Acad Sci U S A. 102:2679-2680.
Katzmann, D.J. and Wendland, B. (2005). Analysis of ubiquitin-dependent protein sorting within the endocytic pathway in Saccharomyces cerevisiae. Methods in Enzymology. 399:192-211.
Watson, H.A., Von Zastrow, M., and Wendland, B. Endocytosis. (2004). In Encyclopedia of Molecular Cell Biology and Molecular Medicine. Second edition. Edited by Robert A. Myers. Wiley-VCH. Volume 4, 181-224.
Miliaras, N.B. and Wendland, B. (2004). EH-proteins: multivalent regulators of endocytosis (and other pathways). Cell Biochemistry and Biophysics. 41:295-318.
Miliaras, N.B., Park, J.-H., and Wendland, B. (2004). The function of the endocytic scaffold protein Pan1p depends on multiple domains. Traffic. 5:963-978.
Aguilar, R.C., Watson, H.A., and Wendland, B. (2003). The yeast epsin Ent1 is recruited to membranes through multiple independent interactions. JBC 278(12):10737-43.
Aguilar, R.C. and Wendland, B. (2003). Ubiquitin: not just for proteasomes anymore. Curr. Opin. in Cell Biol. 15: 184-90.
Shaw, J.D., Hama, H., Sohrabi, F., DeWald, D.B., and Wendland, B. (2003). Phosphatidylinositol (3,5) bisphosphate is required for delivery of endocytic cargo into the multivesicular body.Traffic 4:479-90.
Overstreet, E., Chen, X., Wendland, B., and Fischer, J.A. (2003). Either portion of a severed Drosophila epsin (Liquid Facets) functions in the internalization of Delta in the developing eye.Curr Biol. 13:854-60.
Sekiya-Kawasaki, M., Cope, M.J.T.V., Groen, A.C., Kaksonen, M., Zhang, C., Shokat, K.M., Wendland, B., McDonald, K.L., McCaffery, J.M., and Drubin, D.G. (2003). Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J. Cell Biology. 162:765-72.
Meriin, A.B., Zhang, X., Miliaras, N.B., Kazantsev, A., Chernoff, Y.O., McCaffery, J.M., Wendland, B., and Sherman, M.Y. (2003). Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol. Cell. Biol. 23:7554-65.
Baggett, J.J., D’Aquino, K.E., and Wendland, B. (2003). The Sla2p Talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Genetics. 165:1661-1674.
Baggett, J.J., Shaw, J.D., and Wendland, B. (2003). Fluorescent Labeling of Yeast. Edited by J. Lippincott-Schwartz and P. Matsudaira. Current Protocols in Cell Biology, Unit 4.13.
Babst, M., Katzmann, D.J., Snyder, W.B., Wendland, B., and Emr, S.D. (2002). Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Bodies. Dev. Cell. 3:283-9.
Vida, T.A. and Wendland, B. (2002). Flow cytometry for selection of yeast membrane trafficking mutants. Edited by C. Guthrie and G. Fink. Methods in Enzymology 351: 623-631.
Hurley, J.H. and Wendland, B. (2002). Endocytosis: Driving membranes around the bend. Cell. 111:143-6.
Saiardi, A., Sciambi, C.J., McCaffery, J.M., Wendland, B., and Snyder, S.H. (2002). Inositol pyrophosphates regulate endocytic trafficking. Proc. Natl. Acad. Sci. 99:14206-11.
Wendland, B. Epsins: adaptors in endocytosis? (2002) Nature Rev. Mol. Cell Biol. 3:971-7.
Baggett, J.J., and Wendland, B. (2001). Clathrin function in yeast endocytosis. Traffic.2(5):297- 302.
Wang, G., McCaffery, J.M., Wendland, B., Dupre, S., Haguenauer-Tsapis, R., and Huibregtse, J.M. (2001). Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway. Mol Cell Biol. 21:3564-75.
Wendland, B. (2001). Round-trip ticket: Re-cycling to the plasma membrane requires RME-1. News and Views in Nature Cell Biol. 3(6):E133-5.
Wendland, B. (2001). Everything you ever wanted to know about endocytosis. Review of:Endocytosis, edited by M. Marsh. Volume 36 in Frontiers in Molecular Biology series, edited by B.D. Hames and D.M. Glover. Oxford University Press, 2001. Nature Cell Biology. 3: E254.
Duncan, M.C., Cope, M.J.T.V., Goode, B.L., Wendland, B., and Drubin, D.G. (2001). Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex. Nature Cell Biology. 3(7):687-90.
Shaw, J.D., Cummings, K.B., Huyer, G., Michaelis, S., and Wendland, B. (2001). Yeast as a model system for studying endocytosis. Experimental Cell Research. 271: 1-9.
Watson, H.A., Cope, M.J.T.V., Groen, A.C., Drubin, D.G. and Wendland, B. (2001). In vivo role for Actin Regulating Kinases in endocytosis and yeast epsin phosphorylation. Mol. Biol. Cell. 12(11):3668-79.
Wendland, B., Steece, K.E., and Emr, S.D. (1999) Yeast Epsins contain an essential N-terminal ENTH domain, bind clathrin, and are required for endocytosis. EMBO Journal. 18(16):4383-4393.
Kay, B.K., Yamabhai, M., Wendland, B., and Emr, S.D. (1998). Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Science8: 435-438.
Wendland, B. and Emr, S.D. (1998). Pan1p, yeast eps15, functions as a multivalent adaptor that mediates protein-protein interactions essential for endocytosis. J. Cell Biol. 141: 71-84.
Wendland, B. (1998). For budding yeast investigators. Review of: Methods in Yeast Genetics by A. Adams, D.E. Gottschling, C.A. Kaiser, and T. Stearns. Cold Spring Harbor Laboratory Press, 1997. Trends Cell Biol. 8:462-463.
Babst, M., Wendland, B., Estepa, E.J., and Emr, S.D. (1998). The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17: 2982-2993.
Wendland, B., Emr, S.D., and Riezman, H. (1998). Protein traffic in the yeast endocytic and vacuolar sorting pathways. Curr. Opin. in Cell Biol. 10: 513-522.
Wendland, B., McCaffery, J.M., Xiao, Q. and Emr, S.D. (1996). A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J. Cell Biol. 135: 1485-1500.
Malgaroli, A., Ting, A.E., Wendland, B., Bergamaschi, A., Villa, A., Tsien, R.W., and Scheller, R.H. (1995). Presynaptic component of long-term potentiation visualized at individual hippocampal synapses. Science 268, 1624-1628.
Wendland, B., Schweizer, F.E., Ryan, T.A., Nakane, M., Murad, F., Scheller, R.H., and Tsien, R.W. (1994). Existence of nitric oxide synathase in rat hippocampal pyramidal cells. Proc. Natl. Acad. Sci. 91, 2151-2155.
Wendland, B. and Scheller, R.H. (1994). Molecular mechanism of synaptic vesicle docking and membrane fusion. Semin Neurosci 6: 167-76.
Wendland, B. and Scheller, R.H. (1994). Secretion in AtT-20 cells stably transfected with soluble synaptotagmins. Mol. Endocrinology 8, 1070-1082.
Miller, K.G., Wendland, B., and Scheller, R.H. (1993). Identification of a 34 kd synaptic vesicle and nervous system specific protein. Brain Res., 616, 99-104.
Ryan, T.A., Reuter, H., Wendland, B., Schweizer, F.E., Tsien, R.W., and Smith, S.J. (1993). The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron 11: 713-724.
Wendland, B., Miller, K.G., Schilling, J. and Scheller, R.H. (1991). Differential expression of the p65 gene family. Neuron. 6, 993-1007.
Ngsee, J.K., Miller, K., Wendland, B., and Scheller, R.H. (1990). Multiple GTP-binding proteins from cholinergic synaptic vesicles. J. Neuroscience. 10, 317-322.
Ngsee J.K., Trimble W.S., Elferink L.A., Wendland B., Miller K., Calakos N., Scheller R.H. (1990). Molecular analysis of proteins associated with the synaptic vesicle membrane. Cold Spring Harb Symp Quant Biol. 55:111-8.