Lee Lab Publishes Journal of Neuroscience Paper on Visual Cortex Plasticity


The lab of Hey-Kyoung Lee published a paper titled “Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex” in The Journal of Neuroscience, with CMDB graduate student Gabriela Rodriguez as primary author.  Changes in sensory experience trigger homeostatic adaptation of synapses in the cortex. In this paper, the researchers showed that homeostatic plasticity of excitatory synapses in visual cortex is NMDA receptor dependent, which supports a sliding threshold model of metaplasticity.