{"id":1850,"date":"2025-02-10T14:34:08","date_gmt":"2025-02-10T19:34:08","guid":{"rendered":"https:\/\/krieger.jhu.edu\/mbi\/?post_type=tribe_events&#038;p=1850"},"modified":"2025-04-08T13:53:04","modified_gmt":"2025-04-08T17:53:04","slug":"bodian-seminar-jeanne-paz-ph-d","status":"publish","type":"tribe_events","link":"https:\/\/krieger.jhu.edu\/mbi\/event\/bodian-seminar-jeanne-paz-ph-d\/","title":{"rendered":"Bodian Seminar: Jeanne Paz, Ph.D."},"content":{"rendered":"<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<p class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\tApril 14\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t @ \t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t4:00 pm\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--time\">\n\t\t\t\t\t &#8211; \t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--end\">\n\t\t\t\t\t5:00 pm\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t<\/p>\n<\/div>\n\n\n\n<p>Jeanne Paz, Ph.D.<br>Assistant Professor, Neurology<\/p>\n\n\n\n<p>UCSF Weill Institute for Neurosciences<br>University of California, San Francisco<\/p>\n\n\n\n<p><strong>Deconstructing GABAergic circuits in the thalamus and their role in regulating thalamocortical function<\/strong><\/p>\n\n\n\n<p>The reticular thalamic nucleus (nRT) is involved in perception, sensation, attention, consciousness and in generation of sleep spindle oscillations in thalamocortical networks. The nRT provides the GABAergic inhibitory input to the entire thalamus thus regulating thalamocortical circuit function. Although the GABAergic inhibition of the thalamus has been thoroughly studied, much less is known about the inhibitory tone within the nRT itself. Here we dissected two novel GABAergic pathways that powerfully control the firing of the GABAergic nRT neurons. Using optogenetics and circuit mapping we report the evidence of powerful regulation of nRT neuronal firing by two pathways: a feed-forward intra-nRT GABAergic synaptic inhibition and a non-canonical GABAergic input from basal ganglia\u2019s external segment of the Globus Pallidus. Our findings may have an impact on how the nRT processes incoming information to influence thalamocortical function and behavior (unpublished work).<\/p>\n\n\n\n<p>Faculty Host: Dr. Hey-Kyoung Lee<\/p>\n\n\n<div  class=\"tribe-block tribe-block__venue tribe-clearfix\" >\n\t\n\t\t\n\t<\/div>\n\n\n\t<div  class=\"tribe-block tribe-block__events-link\" >\n\t\t<div class=\"tribe-events tribe-common\">\n\t\t\t<div class=\"tribe-events-c-subscribe-dropdown__container\">\n\t\t\t\t<div class=\"tribe-events-c-subscribe-dropdown\">\n\t\t\t\t\t<div class=\"tribe-common-c-btn-border tribe-events-c-subscribe-dropdown__button\">\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--cal-export tribe-events-c-subscribe-dropdown__export-icon\" \taria-hidden=\"true\"\n\tviewBox=\"0 0 23 17\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M.128.896V16.13c0 .211.145.383.323.383h15.354c.179 0 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8.992.61l.958.958L5 6.517.05 1.566l.958-.958z\" class=\"tribe-common-c-svgicon__svg-fill\"\/>\n<\/svg>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"tribe-events-subscribe-dropdown-content\" class=\"tribe-events-c-subscribe-dropdown__content\">\n\t\t\t\t\t\t<ul class=\"tribe-events-c-subscribe-dropdown__list\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--gcal\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"https:\/\/www.google.com\/calendar\/event?action=TEMPLATE&#038;dates=20250414T160000\/20250414T170000&#038;text=Bodian%20Seminar%3A%20Jeanne%20Paz%2C%20Ph.D.&#038;details=%3Cp%3EJeanne+Paz%2C+Ph.D.%3Cbr+%2F%3EAssistant+Professor%2C+Neurology%3C%2Fp%3E+%3Cp%3EUCSF+Weill+Institute+for+Neurosciences%3Cbr+%2F%3EUniversity+of+California%2C+San+Francisco%3C%2Fp%3E+%3Cp%3E%3Cstrong%3EDeconstructing+GABAergic+circuits+in+the+thalamus+and+their+role+in+regulating+thalamocortical+function%3C%2Fstrong%3E%3C%2Fp%3E+%3Cp%3EThe+reticular+thalamic+nucleus+%28nRT%29+is+involved+in+perception%2C+sensation%2C+attention%2C+consciousness+and+in+generation+of+sleep+spindle+oscillations+in+thalamocortical+networks.+The+nRT+provides+the+GABAergic+inhibitory+input+to+the+entire+thalamus+thus+regulating+thalamocortical+circuit+function.+Although+the+GABAergic+inhibition+of+the+thalamus+has+been+thoroughly+studied%2C+much+less+is+known+about+the+inhibitory+tone+within+the+nRT+itself.+Here+we+dissected+two+novel+GABAergic+pathways+that+powerfully+control+the+firing+of+the+GABAergic+nRT+neurons.+Using+optogenetics+and+circuit+mapping+we+report+the+evidence+of+powerful+regulation+of+nRT+neuronal+firing+by+two+pathways%3A+a+feed-forward+intra%3C%2Fp%3E+%28View+Full+event+Description+Here%3A+https%3A%2F%2Fkrieger.jhu.edu%2Fmbi%2Fevent%2Fbodian-seminar-jeanne-paz-ph-d%2F%29&#038;trp=false&#038;ctz=America\/New_York&#038;sprop=website:https:\/\/krieger.jhu.edu\/mbi\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tGoogle Calendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--ical\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tiCalendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-365\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook 365\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-live\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook Live\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Jeanne Paz, Ph.D.Assistant Professor, Neurology UCSF Weill Institute for NeurosciencesUniversity of California, San Francisco Deconstructing GABAergic circuits in the thalamus and their role in regulating thalamocortical function The reticular thalamic [&hellip;]<\/p>\n","protected":false},"author":729,"featured_media":1880,"template":"","meta":{"_acf_changed":false,"_tec_requires_first_save":false,"_EventAllDay":false,"_EventTimezone":"America\/New_York","_EventStartDate":"2025-04-14 16:00:00","_EventEndDate":"2025-04-14 17:00:00","_EventStartDateUTC":"2025-04-14 20:00:00","_EventEndDateUTC":"2025-04-14 21:00:00","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"$","_EventCurrencyCode":"USD","_EventCurrencyPosition":"prefix","_EventDateTimeSeparator":" @ ","_EventTimeRangeSeparator":" - 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