Affiliations: Neuroscience, Pre-Med
Exploring the Role of Chemokine Receptor 1 (CX3CR1) after Traumatic Brain Injury
Mortality and permanent disabilities from traumatic brain injury (TBI) are major health problems throughout the world, especially for military personnel and auto accident victims. However, TBI currently has no clinically proven effective therapy. This project aims to discover whether microglial/macrophage CX3CR1 is a potential therapeutic target for TBI. CX3CR1 signaling plays an important role in the communication between neurons and resident microglia/migrated macrophages in the brain. By using a combination of genetic, pharmacologic, histologic, MRI, neurobehavioral, and molecular biologic strategies, this study will test the hypothesis that CX3CR1-deficient mice have better histologic and functional outcomes than CX3CR1 wild-type mice.
Mentor: Dr. Jian Wang