The Johns Hopkins Program in Latin American Studies was founded in 1989. For nearly thirty years, it was the home for the academic study of Latin America on the Homewood campus.

In 2018, the deans of the Krieger School of Arts and Sciences supported a multi-year initiative led by a new cohort of junior faculty, Latin America in a Globalizing World.

In 2022, the Program in Latin American, Caribbean, and Latinx Studies was relaunched with a new cross-divisional faculty advisory board.