Since 2025, Ksenia Tatarchenko has been teaching in the Medicine, Science, and the Humanities program at Johns Hopkins University. Previously, she held positions as an assistant professor of science and technology studies at the College of Integrative Studies at Singapore Management University (2019–2024), a lecturer at the Global Studies Institute at the University of Geneva, a visiting assistant professor of history at NYU Shanghai, and a postdoctoral fellow at the Harriman Institute at Columbia University. In 2025–2026, she is a fellow at the JHU Alexander Grass Humanities Institute. She serves as an associate editor at the IEEE Annals of the History of Computing.

Tatarchenko is the author of Soviet SCI_BERIA: The Novosibirsk Science Center and the Late Soviet Politics of Expertise (Bloomsbury, 2024), which uses numerical computation and programming as a lens to explore regional transformation and late Soviet modernity. She co-edited two special issues: “Mathematical Superpowers: The Politics of Universality in a Divided World,” a special issue of Historical Studies in the Natural Sciences 46, no. 5 (2016), with Christopher Phillips; and “Governing Science, Governing by Science: The Lives of Late Soviet Science (1945–1991),” Les Cahiers du Monde Russe 63, no. 1 (2022), with Grégory Dufaud. She publishes on the history of the Soviet Information Age, including its distinct materiality, alternative algorithmic rationality, and professionalization cultures and is currently working on a second book manuscript on the history of Soviet cybernetics, tentatively titled Erring Humans, Learning Machines.