Over the past two years, the COVID-19 pandemic has put local and global public health infrastructure to the test, revealing countless opportunities for navigating and improving the many facets of modern public health challenges. To highlight the importance of exploration and innovation in these uncertain times, we proudly present to you, “Uncharted Territories”. As you peruse this issue, the Epidemic Proportions team encourages you to reflect on your own experiences throughout the pandemic and to expand your knowledge about the numerous global health issues that arose alongside COVID-19 this past year. We hope you cherish this volume of Epidemic Proportions as much as the staff and authors enjoyed publishing it! Available now on https://issuu.com/epidemicproportions/docs/vol18-2021.